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BVR-A is a direct target of the IR kinase activity, and as part of a regulatory loop BVR-A phosphorylates IRS1 on inhibitory Ser residues to prevent IRS1 aberrant activation in response to IR

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Finally, the Cas9 protein of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 system has been implicated in meningococcal ability to adhere to and invade the host cell, and especially to survive in the intracellular environment (Sampson et al., 2013)